Eduardo Gade Gusmao

RGT is a Python package for integrative analysis of regulatory genomics data, offering tools for peak calling, binding site prediction, and regulatory factor association.

The paper shows RNA polymerase II is necessary for spatial chromatin reorganization after mitosis, as demonstrated by Hi-C and in silico modeling.

This study identifies HMGB1 as an RNA-binding protein that coordinates chromatin folding and RNA homeostasis in senescence through interactions with other RBPs and regulation of SASP-related transcripts.

Bloom is a method for analyzing 3C-type data that retrieves hidden interaction patterns and detects enhancer-promoter interactions with a frequency score, enabling the decoding of regulatory landscapes.

The paper identifies HMGB2 loss as an early event in senescence that disrupts chromatin organization by inducing CTCF clustering across multiple human cell types.