Targeting the hyperactive STAT3/5 pathway in cutaneous T-cell lymphoma with the multi-kinase nuclear transporter inhibitor IQDMA
Saptaswa Dey, Helena Sorger, Michaela Schlederer, Isabella Perchthaler, Martin Lothar Metzelder, Lukas Kenner, Richard Moriggl, Peter Wolf
This study evaluates IQDMA, a multi-kinase inhibitor, as a targeted therapy for cutaneous T-cell lymphoma, showing significant tumor volume reduction and STAT3/5 pathway inhibition compared to PUVA.
bioRxiv · Mar 3, 2025 · PreprintCancer Biology