Systematic disruption of zebrafish fibrillin genes identifies a translational zebrafish model for Marfan syndrome
Karo De Rycke, Marina Horvat, Lisa Caboor, Petra Vermassen, Griet De Smet, Sophie Lobbestael, Marta Santana Silva, Wouter Steyaert, Matthias Van Impe, Patrick Segers, Julie F A De Backer, Patrick Yves Sips
This paper creates a zebrafish model of Marfan syndrome by disrupting fibrillin genes, finding that fbn2b-/- zebrafish exhibit cardiovascular phenotypes similar to human disease.
JACC Basic to Translational Science · Apr 22, 2026Peer-reviewedGenetics