Author

Michael Brent Hawkins

Boston Children's HospitalORCID 0000-0002-5164-2893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:zebrafish· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:comparative / phylogenetic analysis· 2 Research Focus:development & morphogenesis· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Matthew P. HarrisiD· 4 shared Andy WillaertiD· 1 shared Anne De PaepeiD· 1 shared Aurélie HintermanniD· 1 shared Bénédicte MascreziD· 1 shared Brecht GuillemyniD· 1 shared Charlotte Gistelinck· 1 shared Christopher Chase BoltiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersEvolutionary Biology

Matthew P. HarrisORCID

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4 papers

Recent·Most cited

EVOLUTIONARY CO-OPTION OF AN ANCESTRAL CLOACAL REGULATORY LANDSCAPE DURING THE EMERGENCE OF DIGITS AND GENITALS

Aurélie Hintermann, Christopher Chase Bolt, Michael Brent Hawkins, Guillaume Valentin, Lucille Lopez‐Delisle, Madeline M. Ryan, Sandra Gitto, Paula Barrera Gómez, Bénédicte Mascrez, Thomas A. Mansour, Tetsuya Nakamura, Matthew P. Harris, Neil H. Shubin, Denis Duboule

The paper shows that the regulatory landscape controlling Hoxd gene expression in limbs was co-opted from an ancestral cloacal program in tetrapods.

Nature · Sep 17, 2025Peer-reviewedEvolutionary Biology

Establishment, conservation, and innovation of dorsal determination mechanisms during the evolution of vertebrate paired appendages

Michael Brent Hawkins, Sofía Zdral, Silvia Naranjo, Miguel Juliá, Manuel Sánchez‐Martín, Jacob M. Daane, Nicolás Cumplido, Dávid Jandzík, Daniel Meulemans Medeiros, Sarah K. McMenamin, Matthew P. Harris, Juan J. Tena, María A. Ros

The paper identifies ancestral dorsal-ventral patterning mechanisms in fish fins and shows evolutionary innovations in their regulation.

bioRxiv · Jul 2, 2025 · PreprintEvolutionary Biology

Apical expansion of calvarial osteoblasts and suture patency is dependent on graded fibronectin cues

Xiaotian Feng, Helen Molteni, Megan Gregory, Jennifer Lanza, Nikaya Polsani, Isha Gupta, Rachel H. Wyetzner, Michael Brent Hawkins, Greg Holmes, Sevan Hopyan, Matthew P. Harris, Radhika P. Atit

This study shows that graded Fibronectin (FN1) cues guide calvarial osteoblast migration and suture patency, with disruptions in FN1 or related pathways causing craniosynostosis in mice.

Development · Apr 1, 2024Peer-reviewedDevelopmental Biology

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

Charlotte Gistelinck, Ronald Young Kwon, Fransiska Malfait, Sofie Symoens, Matthew P. Harris, Katrin Henke, Michael Brent Hawkins, Shannon Fisher, Patrick Yves Sips, Brecht Guillemyn, Jan Willem Bek, Petra Vermassen, Hanna De Saffel, P. Eckhard Witten, MaryAnn Weis, , Paul J. Coucke

This study shows zebrafish mutants with type I collagen mutations closely mimic human collagenopathies, revealing phenotypic variability linked to disease severity and potential for identifying genetic modifiers.

Proceedings of the National Academy of Sciences · Aug 6, 2018Peer-reviewedGenetics