Novel Compensatory Mechanisms Enable the Mutant KCNT1 Channels to Induce Seizures
Salleh N. Ehaideb, Gentry T. Decker, Petrina Smith, Daniel Davis, Bing Zhang
The paper shows that gain-of-function KCNT1 mutations cause seizures by silencing inhibitory neurons and inducing compensatory plasticity in motoneurons in Drosophila.
bioRxiv · Oct 2, 2017 · PreprintNeuroscience