Bing Zhang

The paper creates a novel mouse model of KCNT1-related epilepsy carrying the G269S variant and demonstrates its phenotypic effects in vitro and in vivo.

The paper shows that flight impairments in Drosophila increase sleep through a novel neural pathway involving structural plasticity in projection neurons.

The paper shows that gain-of-function KCNT1 mutations cause seizures by silencing inhibitory neurons and inducing compensatory plasticity in motoneurons in Drosophila.