Phenotypic Antibiotic Susceptibility Testing at the limit of one bacterial cell
Lisa Johansson, Irfan Ahmad, Jimmy Larsson, Spartak Zikrin, Petter Knagge, David Fange, Johan Elf
This study evaluates if phenotypic antibiotic susceptibility testing can be performed on single bacterial cells by monitoring phenotypic changes over time, finding that single-cell responses are heterogeneous and require sequential antibiotic exposure for accurate resistance classification.
bioRxiv · Apr 13, 2025 · PreprintMicrobiology