Spartak Zikrin

The LacI hinge region balances binding stability against inducibility

This study investigates how mutations in the hinge region of LacI affect binding stability and inducibility, showing a trade-off between binding strength and inducibility rather than speed and stability.

Phenotypic Antibiotic Susceptibility Testing at the limit of one bacterial cell

This study evaluates if phenotypic antibiotic susceptibility testing can be performed on single bacterial cells by monitoring phenotypic changes over time, finding that single-cell responses are heterogeneous and require sequential antibiotic exposure for accurate resistance classification.

Anti-correlation of LacI association and dissociation rates observed in living cells

The paper measures association and dissociation rates of LacI binding sites in living cells and finds an anti-correlation between these rates, challenging the assumption that binding site strength is solely determined by dissociation rate.