David Fange

This study investigates how mutations in the hinge region of LacI affect binding stability and inducibility, showing a trade-off between binding strength and inducibility rather than speed and stability.

This study evaluates if phenotypic antibiotic susceptibility testing can be performed on single bacterial cells by monitoring phenotypic changes over time, finding that single-cell responses are heterogeneous and require sequential antibiotic exposure for accurate resistance classification.

This study uses live-cell imaging of fluorescently labeled loci in E. coli to inform a dynamic polymer model of chromosome organization across the cell cycle, revealing global reorganization of the chromosome structure.

The paper demonstrates in situ genotyping of pooled strain libraries by combining single molecule fluorescence imaging with barcoded plasmids to identify individual cell genotypes after phenotype characterization.