Alcohol and Opioids Modulate Excitatory Inputs to the SCN
William Purvines, Valerie Vierkant, Peyton Westbo, Xuehua Wang, Jeff R. Jones, David J. Earnest, Jun Wang
This study shows that alcohol and opioids modulate glutamatergic input to the SCN, revealing the SCN as a target of depressant substances and highlighting glutamatergic transmission as a vulnerability in circadian dysregulation.
bioRxiv · May 4, 2026 · PreprintNeuroscience