William Purvines

This study shows that alcohol and opioids modulate glutamatergic input to the SCN, revealing the SCN as a target of depressant substances and highlighting glutamatergic transmission as a vulnerability in circadian dysregulation.

This study shows that traumatic brain injury increases alcohol consumption and impairs cognition by reducing cholinergic activity and increasing microglial cells in mice.

This study shows that prenatal alcohol exposure reduces cholinergic interneurons and their activity in the striatum, leading to impaired cognitive flexibility and compulsive drinking behaviors in adult offspring.

This study shows that chronic opioid use induces GABAergic plasticity in striatal neurons, leading to hypodopaminergic states and negative affect, which contribute to relapse.