The paper introduces a software environment for long-term fiber photometry analysis that enables revisitable, reproducible workflows with post-run correction and event reanalysis.

eNeuro · Sep 24, 2026Peer-reviewedNeuroscience

A direct SCN-to-DMH output pathway organizes circadian behavioral timing

Nicole E Keene, Farina Pourmir, Ethan Hang, Mustafa Ozturgut, Dylan A. McCreedy, Jeff R. Jones

This study identifies a direct SCN-to-DMH pathway that organizes circadian locomotor timing by showing that intact DMH neurons, not local molecular clocks, are required for rhythmic behavior.

bioRxiv · May 22, 2026 · PreprintNeuroscience

Alcohol and Opioids Modulate Excitatory Inputs to the SCN

William Purvines, Valerie Vierkant, Peyton Westbo, Xuehua Wang, Jeff R. Jones, David J. Earnest, Jun Wang

This study shows that alcohol and opioids modulate glutamatergic input to the SCN, revealing the SCN as a target of depressant substances and highlighting glutamatergic transmission as a vulnerability in circadian dysregulation.

bioRxiv · May 4, 2026 · PreprintNeuroscience

Circadian modulation of spontaneous dopamine release shapes reward-evoked signaling in the nucleus accumbens

Jordan N. Cook, Mikael GEVORGYAN, Jason Armitage, Jeff R. Jones

This study shows circadian rhythms modulate dopamine release and reward behavior, with distinct patterns for spontaneous and reward-evoked dopamine.

bioRxiv · Apr 24, 2026 · PreprintNeuroscience

Diurnality reconfigures circadian network dynamics in the suprachiasmatic nucleus

Vanessa Muhl, Daniela Lopez-Lorenzo, Farina Pourmir, Samantha O. Sweck, Daisuke Ono, Jeff R. Jones

This study compares SCN network dynamics in diurnal and nocturnal mice, finding species-specific differences in molecular clock rhythms and spatial timing organization.

bioRxiv · Feb 28, 2026 · PreprintNeuroscience

Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling

Olajumoke Ogunlusi, Mrinmoy Sarkar, Kayla Carter, Arhit Chakrabarti, Devon J. Boland, Tristan Nguyen, James Sampson, Christian N. Nguyen, Danielle M Fails, Yava Jones‐Hall, Loning Fu, Gus A. Wright, Da Mi Kim, James J. Cai, Bani K. Mallick, , Tapasree Roy Sarkar

This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.

Oncogene · Oct 16, 2025Peer-reviewedCancer Biology

A circadian behavioral analysis suite for real-time classification of daily rhythms in complex behaviors

L. J. Perry, Gavin E. Ratcliff, Arthur Mayo, Blanca Perez, Larissa Rays Wahba, K. L. Nikhil, William C. Lenzen, Yangyuan Li, Jordan S Mar, Isabella Farhy-Tselnicker, Wanhe Li, Jeff R. Jones

The paper develops a system for real-time classification of circadian rhythms in complex mouse behaviors, finding sex and estrogen influence several circadian properties.

Cell Reports Methods · May 1, 2025Peer-reviewedAnimal Behavior & Cognition

Entrainment of circadian rhythms depends on firing rates and neuropeptide release of VIP SCN neurons

Cristina N. Mazuski, John H. Abel, Samantha P. Chen, Tracey O. Hermanstyne, Jeff R. Jones, Tatiana Simon, Francis J. Doyle, Erik D. Herzog

This study identifies how VIP SCN neurons use firing rates and neuropeptide release to entrain circadian rhythms in gene expression and behavior.

Neuron · Jul 14, 2018Peer-reviewedNeuroscience

Circadian clock neurons mediate time-of-day dependent responses to light

Jeff R. Jones, Tatiana Simon, Lorenzo Lones, Erik D. Herzog

This study investigates how circadian clock neurons in the suprachiasmatic nucleus (SCN) respond to light and mediate time-of-day dependent rhythms in behavior.

bioRxiv · Apr 4, 2018 · PreprintNeuroscience