Protein structure, a genetic encoding for glycosylation
Benjamin P. Kellman, Daniel R. Sandoval, Olga O. Zaytseva, Kelly P. Brock, Sabyasachi Baboo, Daniela Nachmanson, Edward B. Irvine, Sanne Schoffelen, Erick Armingol, Nathan Mih, Yujie Zhang, Mia Jeffris, Philip Bartels, Thi Nguyen, Amy Sze Pui Tam, , Nathan E. Lewis
The paper identifies a relationship between protein structure and glycan structure, introducing a glycoimpact matrix to predict glycosylation patterns and validate it through disease variants and engineered antibodies.
bioRxiv · May 15, 2024 · PreprintGenetics