Christina J. Sigurdson

This study shows that phosphatase reduction and receptor hyperphosphorylation occur early in prion disease and precede inflammation.

This study shows that reducing AQP4 function in a prion-CAA mouse model prolongs survival and reduces neuroinflammation without affecting prion spread.

This study shows that Hrs, an ESCRT-0 protein, modulates AMPA receptor currents and Ca2+-dependent signaling by sensing and responding to neuronal activity at synapses.

The paper shows that PrPC ligands in human neurons trigger PLCγ1 signaling and an Arc/Arg3.1 response, indicating neuronal hyperactivity in prion disease.

The paper identifies a relationship between protein structure and glycan structure, introducing a glycoimpact matrix to predict glycosylation patterns and validate it through disease variants and engineered antibodies.