A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells
Galbha Duggal, Xinyu Li, Philippa Pettingill, Tatjana Lalic, Shailesh Kumar Gupta, Christine Flodgaard Høgsbro, Viola Volpato, Caleb Webber, Rory J. Bowden, Despoina Charou, Kanisa Arunasalam, Marcello Maresca, Ryan Hicks, Satyan Chintawar, M. Zameel Cader
This paper describes a method to efficiently differentiate human iPSC into peptidergic nociceptors expressing CGRP and TRPV1, with functional maturity and drug response.
Stem Cell Reports · Jun 25, 2026Peer-reviewedNeuroscience