Viola Volpato

This paper describes a method to efficiently differentiate human iPSC into peptidergic nociceptors expressing CGRP and TRPV1, with functional maturity and drug response.

This study shows that astrocytes derived from LMX1A+ progenitors lose lineage composition during differentiation unless progenitors are purified, using deep single-cell RNA sequencing.

The paper constructs a single-cell atlas of the Substantia nigra and identifies cell-specific gene expression patterns linked to Parkinson's disease and neuropsychiatric disorders.

This study identifies cell-type-specific expression of dystonia-associated genes and links them to shared genetic and biological mechanisms with psychiatric disorders.

This study identifies novel drug treatments for spinal muscular atrophy by integrating multi-omics data and drug perturbation profiles, showing harmine improves disease phenotypes in models.