Evaluating transportability of in-vitro cellular models to in-vivo human phenotypes using gene perturbation data
Laurence J Howe, Yurii S. Aulchenko, George Davey Smith, Neil M Davies, Jorge Esparza-Gordillo, Toby Johnson, Jimmy Z. Liu, Tom G. Richardson, Philippe Sanséau, Robert A. Scott, Daniel D. Seaton, Ashwini Kumar Sharma, Adrián Cortés
The paper evaluates the transportability of in-vitro gene perturbation models to in-vivo human phenotypes using CRISPR data and UK Biobank, finding some models are predictive while others are not.
Nature Communications · Dec 13, 2025Peer-reviewedGenetics