Evren U. Azeloglu

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

The paper identifies cardiotoxic drug signatures using bulk transcriptomics and integrates them with genomic and single-cell data to predict toxicity mechanisms.

The paper identifies four SNPs in the LILRB3 gene associated with graft failure in African American kidney transplant recipients and links them to immune-related diseases.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

The paper uses dynamical modeling to show how different network motifs process oscillatory signals, identifying motifs that suppress or convert oscillations into sustained outputs.

The paper constructs a reference tissue atlas of the human kidney using multi-omics data to identify cell types, pathways, and genes across nephron segments and interstitium.

This study identifies Plexin-B2 as a regulator of cell mechanics during multicellular organization, showing its role in modulating cell stiffness, contractility, and differentiation in human stem and progenitor cells.

This paper introduces structural gene expression signatures (sGES) derived from protein structure features, showing their utility in identifying robust biological signatures across datasets and experimental platforms.

The paper constructs a tissue- and organ-based subcellular-function atlas of obesity-related genes and pathways using publicly available datasets and integration methods.

This study identifies WT1 as a transcriptional repressor that decreases memory strength and promotes memory flexibility by regulating synaptic plasticity and learning outcomes.

This study compares 3-DGE and conventional mRNAseq, finding similar gene expression results with 3-DGE offering cost savings and scalability.