Remyelinating therapy reverses neuronal activity suppression in a mouse model of demyelination
Aniruddha Das, Julie A. Borovicka, Hale Tobin, Rajaram Kshetri, Shruti Bhatia, Jacob Icardi, Ghazaal Tahmasebi, Priyanka Agochiya, Shriya Singh, Jordon Manworren, Philopater Isak, Willow Lev, Bruce D. Trapp, Tara M. DeSilva, Hod Dana
This study shows that remyelinating therapy with clemastine restores neuronal activity in a mouse model of demyelination, with sex-dependent recovery patterns.
bioRxiv · Feb 3, 2025 · PreprintNeuroscience