Hod Dana

Early Increases in Hippocampal Synchrony Predict Chronic Epileptiform Burden in a Temporal Lobe Epilepsy Model

Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol Abuse

This study shows that preventing microglial reactivity protects against acute and progressive neurological dysfunction and motor impairments caused by alcohol abuse in mice.

Remyelinating therapy reverses neuronal activity suppression in a mouse model of demyelination

This study shows that remyelinating therapy with clemastine restores neuronal activity in a mouse model of demyelination, with sex-dependent recovery patterns.

Systemic exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the living mouse brain

This study shows that systemic exposure to SARS-CoV-2 virus-like particles disrupts cortical neuronal activity in mice, with persistent effects and heightened vulnerability in htau mice.

Longitudinal in vivo monitoring of axonal integrity after brain injury

This study develops an in vivo method to monitor axonal activity over time in mice and shows that P7C3-A20 reduces but does not eliminate axonal dysfunction after brain injury.

Recording large-scale, cellular-resolution neuronal activity from freely-moving mice

This paper introduces a method to record single-cell cortical activity from freely-moving mice using CaMPARI, revealing task-dependent activity patterns in motor and somatosensory cortices.

Cellular-resolution monitoring of ischemic stroke pathologies in the rat cortex

This study uses two-photon microscopy to monitor functional changes in rat cortical regions after ischemic stroke, revealing widespread neuronal activity modifications across multiple brain areas.

Reversible loss of Hippocampal Function in a Mouse Model of Demyelination/Remyelination

The paper monitors hippocampal neuronal activity during demyelination and remyelination in mice, finding reduced firing rates during demyelination and partial recovery after remyelination.

Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo

The paper presents transgenic mice expressing the red calcium indicator jRGECO1a for in vivo neuronal imaging, showing comparable or better signal-to-noise ratios than viral methods.

High-performance GFP-based calcium indicators for imaging activity in neuronal populations and microcompartments

Structure-guided mutagenesis of GCaMP6 plus neuron-based screening yields a jGCaMP7 family, each variant tuned to a different regime: single spikes, neurites and neuropil, or population imaging.

Sensitive red protein calcium indicators for imaging neural activity

The paper introduces improved red calcium indicators that match the sensitivity of GFP-based indicators, enabling better in vivo neural activity imaging.