Bruce D. Trapp

NeuroPupil improves cross-species pupillometry with a deep learning framework, achieving better accuracy and efficiency while enabling reliable biological insights.

The paper identifies M1 muscarinic and H3 histamine receptors as targets for OPC differentiation and analyzes their ligand interactions using computational methods.

This study shows that remyelinating therapy with clemastine restores neuronal activity in a mouse model of demyelination, with sex-dependent recovery patterns.

This study integrates multi-omics data using network medicine to identify potential drug targets and repurposable treatments for ALS.

This study shows that p38γMAPK inhibits oligodendrocyte differentiation and myelin repair, and is enriched in multiple sclerosis lesions.

The paper assesses axonal mitochondrial content and complex IV activity in multiple experimental disease models of MS, finding that increased mitochondrial content does not always correlate with increased COX activity, and that COX activity inversely correlates with axonal injury.

The paper uses snRNA-seq to compare cell type-specific transcriptomic changes between RRMS and SPMS in non-lesioned brain regions, identifying downregulation of astrocytic sphingosine kinases in SPMS.

This study identifies SPMS-enriched microglia subsets with disrupted iron homeostasis and oxidative stress using snRNA-seq and validates findings with histology and RNA-scope.

The paper monitors hippocampal neuronal activity during demyelination and remyelination in mice, finding reduced firing rates during demyelination and partial recovery after remyelination.