Autophagic cargo in Lewy bodies: are Lewy bodies a compartment for spatial protein quality control?
Phoebe Conod, Nicola Charlesworth, Paweł Palmowski, Andrew Porter, Lauren Walker, Omar M. A. El‐Agnaf, Viktor I. Korolchuk, Tiago F. Outeiro, Daniel Erskine
The paper investigates whether Lewy bodies form due to impaired autophagy and mitochondrial dysfunction, finding enriched autophagic markers and proteomic evidence of aggresome-like pathways in Lewy bodies.
bioRxiv · Sep 24, 2023 · PreprintNeuroscience