Author

Omar M. A. El‐Agnaf

Hamad bin Khalifa UniversityORCID 0000-0002-6850-8084Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:flow cytometry· 1 Approach:machine learning (classical)· 1 Organism:non-human primate· 1 Assay:protein structure· 1

Frequent Co-Authors

Daniel ErskineiD· 2 shared Nishant N. VaikathiD· 2 shared Tiago F. OuteiroiD· 2 shared Abdelilah ArredouaniiD· 1 shared Abdi Adam· 1 shared Abdullah AldushainiD· 1 shared Adviti NaikiD· 1 shared Ahmed ZaqoutiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Daniel ErskineORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Longitudinal cellular and humoral immune responses following Covid-19 BNT162b2-mRNA-based booster vaccination of craft and manual workers in Qatar.

Remy Thomas, Ahmed Zaqout, Bakhita Meqbel, Umar Jafar, Nishant N. Vaikath, Abdullah Aldushain, Adviti Naik, Hibah Shaath, Neyla S. Al-Akl, Abdi Adam, Houda Yasmine Ali Moussa, Kyung Chul Shin, Rowaida Ziad Taha, Mohammed Abukhattab, Muna A. Rahman S. AlMaslamani, , Julie V. Decock

This study examines immune responses in craft and manual workers after a BNT162b2 booster, showing enhanced Th1 and cytotoxic T cell responses, and durable humoral immunity, with prior infection boosting B cell counts.

Frontiers in Immunology · Mar 27, 2025Peer-reviewedImmunology

Seed-competent alpha-synuclein pathology in metachromatic leukodystrophy: the expanding spectrum of alpha-synucleinopathy in sphingolipidoses

Simona S. Ghanem, Jade I. Hawksworth, Searlait Thom, Annabelle E. Hartanto, Joseph O’Neill, Janarthanan Ponraj, Said A Mansour, Johannes Attems, Angela Pyle, Lauren R. Johnson, Jack P. Baines, Robert William Taylor, Tiago F. Outeiro, Omar M. A. El‐Agnaf, Daniel Erskine

This study examines alpha-synuclein pathology in metachromatic leukodystrophy (MLD) brain tissue, finding seed-competent alpha-synuclein conformers in juvenile-onset cases, similar to Lewy body diseases.

bioRxiv · Aug 9, 2024 · PreprintNeuroscience

Autophagic cargo in Lewy bodies: are Lewy bodies a compartment for spatial protein quality control?

Phoebe Conod, Nicola Charlesworth, Paweł Palmowski, Andrew Porter, Lauren Walker, Omar M. A. El‐Agnaf, Viktor I. Korolchuk, Tiago F. Outeiro, Daniel Erskine

The paper investigates whether Lewy bodies form due to impaired autophagy and mitochondrial dysfunction, finding enriched autophagic markers and proteomic evidence of aggresome-like pathways in Lewy bodies.

bioRxiv · Sep 24, 2023 · PreprintNeuroscience

Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates

Mathieu Bourdenx, Aurélien Nioche, Sandra Doveró, Marie-Laure Arotçarena, Sandrine M. J. Camus, Grégory Porras, Marie-Laure Thiolat, Nicolas P. Rougier, Annick Prigent, Philippe Aubert, Sylvain Bohic, Christophe Sandt, Florent Laferrière, Évelyne Doudnikoff, Niels Kruse, , Erwan Bézard

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.

Science Advances · May 13, 2020Peer-reviewedNeuroscience