Andrew Porter

Functional Differentiation of GH172 Arabinofuranosidases Through Divergent Quaternary Structures

The paper identifies functional and structural differences among three GH172 arabinofuranosidases from Dysgonomonas gadei using synthetic substrates, covalent inhibitors, and structural analysis.

DNA Traces on the Shroud of Turin: Metagenomics of the 1978 Official Sample Collection

The paper analyzes DNA and metagenomic data from the 1978 Shroud of Turin samples, revealing human mtDNA lineages, microbial communities, and contaminants, while radiocarbon dating indicates repair events in the 16th and 17th centuries.

The evolution lifecycle of ribosome hibernation factors

The paper analyzes 46,015 bacterial genomes to show hibernation factors evolved from large proteins, reduced in size, and were lost in over 10% of species, with some bacteria borrowing factors from others.

Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)

The paper evaluates protein quantitation in DIA proteomics using controlled experiments on two mass spectrometry platforms, identifying over 10,000 proteins and highlighting the impact of post-processing on accuracy and false quantitative rates.

Autophagic cargo in Lewy bodies: are Lewy bodies a compartment for spatial protein quality control?

The paper investigates whether Lewy bodies form due to impaired autophagy and mitochondrial dysfunction, finding enriched autophagic markers and proteomic evidence of aggresome-like pathways in Lewy bodies.

Inflammation and autophagy dysfunction in metachromatic leukodystrophy: a central role for mTOR?

This study identifies inflammation and autophagy dysfunction, linked to mTOR pathway activation, as key mechanisms in metachromatic leukodystrophy using postmortem tissue analysis.