Paweł Palmowski

This study investigates neuroinflammation and metabolic dysfunction in POLG-related mitochondrial epilepsy using post-mortem brain tissues and proteomic analysis.

The paper analyzes DNA and metagenomic data from the 1978 Shroud of Turin samples, revealing human mtDNA lineages, microbial communities, and contaminants, while radiocarbon dating indicates repair events in the 16th and 17th centuries.

The paper analyzes 46,015 bacterial genomes to show hibernation factors evolved from large proteins, reduced in size, and were lost in over 10% of species, with some bacteria borrowing factors from others.

The paper evaluates protein quantitation in DIA proteomics using controlled experiments on two mass spectrometry platforms, identifying over 10,000 proteins and highlighting the impact of post-processing on accuracy and false quantitative rates.

The paper identifies Clostridium species that metabolize human milk oligosaccharides, producing beneficial metabolites and suppressing inflammation and pathogen growth in preterm infants.

The paper investigates whether Lewy bodies form due to impaired autophagy and mitochondrial dysfunction, finding enriched autophagic markers and proteomic evidence of aggresome-like pathways in Lewy bodies.

This study identifies inflammation and autophagy dysfunction, linked to mTOR pathway activation, as key mechanisms in metachromatic leukodystrophy using postmortem tissue analysis.