Phosphoinositide- and Collybistin-Dependent Synaptic Clustering of Gephyrin
Nele Burdina, Filip Liebsch, Arthur Macha, Joaquín Lucas Ortuño Gil, Pia Frommelt, Irina Rais, Fabian Basler, Simon Poepsel, Günter Schwarz
This study identifies the molecular mechanism of gephyrin clustering at GABAergic synapses, showing collybistin and phosphoinositides drive high-molecular weight complex formation, while gephyrin phosphorylation at Ser325 disrupts it.
Journal of Neurochemistry · Aug 1, 2025Peer-reviewedBiochemistry