Author

Irina Rais

Max Planck Institute for Biology of AgeingORCID 0000-0002-0367-1980Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrea MesarosiD· 1 shared Arthur MachaiD· 1 shared Bruna Martins GarciaiD· 1 shared Fabian BasleriD· 1 shared Filip LiebschiD· 1 shared Günter SchwarziD· 1 shared Joaquín Lucas Ortuño Gil· 1 shared Kira AllmerothiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Andrea MesarosORCID

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2 papers

Recent·Most cited

Phosphoinositide- and Collybistin-Dependent Synaptic Clustering of Gephyrin

Nele Burdina, Filip Liebsch, Arthur Macha, Joaquín Lucas Ortuño Gil, Pia Frommelt, Irina Rais, Fabian Basler, Simon Poepsel, Günter Schwarz

This study identifies the molecular mechanism of gephyrin clustering at GABAergic synapses, showing collybistin and phosphoinositides drive high-molecular weight complex formation, while gephyrin phosphorylation at Ser325 disrupts it.

Journal of Neurochemistry · Aug 1, 2025Peer-reviewedBiochemistry

Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism

Tania Medeiros, Silvia Reato, Xianhe Li, Bruna Martins Garcia, Irina Rais, Kira Allmeroth, Matías Daniel Hartman, Martin Sebastian Denzel, Martin Purrio, Andrea Mesaros, Kit‐Yi Leung, Nicholas D. E. Greene, Patrick Giavalisco, Lena F. Pernas

The paper shows ATF4 rewires mitochondrial one-carbon metabolism during infection to restrict Toxoplasma growth via folate competition.

bioRxiv · May 7, 2025 · PreprintCell Biology