Cell BiologybioRxivPreprint
Spatial proteomics identifies altered thick ascending limb cells as drivers of kidney disease through uromodulin retention
Azuma Nanamatsu, George J. Rhodes, William S. Bowen…·Tarek M. El‐Achkar
This study identifies altered thick ascending limb cells with UMOD retention as drivers of CKD using spatial proteomics and shows reducing UMOD retention attenuates CKD development.