GenomicsGenome ResearchPeer-reviewed
High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue-specificity
Kaia Mattioli, Pieter-Jan Volders, Chiara Gerhardinger…·John L. Rinn
The paper uses computational methods and MPRA to analyze lncRNA and mRNA promoters, finding that divergent promoters have higher transcriptional activity and lower tissue-specificity, while lincRNAs and eRNAs are more tissue-specific with simpler TF motif profiles.
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