Chiara Gerhardinger

This study uses snRNA-seq to track the transcriptional changes in adult hippocampal neurons from birth to maturity, identifying key transcription factors and molecular switches involved in their differentiation.

The paper presents a single-cell multiomics atlas of human cortical organoid development, revealing molecular programs of cellular diversification and identifying human-specific gene roles in lineage establishment.

The paper identifies human-specific enrichment of schizophrenia risk genes in callosal neurons of the developing neocortex using comparative transcriptomic analysis across species and developmental stages.

The paper uses CRISPR interference to identify lncRNA loci critical for differentiation and pluripotency in human embryonic stem cells.

The paper identifies a causal variant in a super-enhancer that disrupts an NF-κB regulatory circuit, leading to T-cell activation in immune-mediated diseases.

The paper measures cis and trans effects on regulatory elements between human and mouse to show cis-trans compensation is uncommon within individual elements.

This study shows that Firre and Dxz4 deletions in mice affect autosomal gene regulation without impacting XCI.

The paper uses computational methods and MPRA to analyze lncRNA and mRNA promoters, finding that divergent promoters have higher transcriptional activity and lower tissue-specificity, while lincRNAs and eRNAs are more tissue-specific with simpler TF motif profiles.

The paper identifies Tug1 as essential for male fertility, showing it has three distinct regulatory activities: a cis DNA repressor, a trans-acting lncRNA, and a conserved peptide affecting mitochondrial function.

The paper identifies RNA sequences responsible for nuclear enrichment in lncRNAs using a modified MPRA approach and validates findings with smRNA-FISH.

The paper identifies differences in chromatin environment, transcriptional regulation, and splicing between lincRNAs and mRNAs in human cell lines.