SERPINE1-AP2A1 interplay links substrate stiffness to fibroblast senescence
Intan Chairun Nisa, Pirawan Chantachotikul, Takumi Saito, Cristina Bertocchi, Shinji Deguchi
This study shows that substrate stiffness influences fibroblast senescence through the SERPINE1-AP2A1 interaction, affecting cytoskeletal remodeling and senescence-associated secretory phenotype factors.
bioRxiv · Jul 1, 2026 · PreprintCell Biology