Shinji Deguchi

Mechanoadaptive focal adhesion-actomyosin coupling organizes diverse modes across ECM stiffness

The paper develops a dynamical model to show how ECM stiffness and mechanoadaptive processes generate diverse focal adhesion modes and influence their stability.

Mechanical stretch disrupts intracellular structures under impaired actin integrity in vascular smooth muscle cells

This study investigates how mechanical stretch affects actin-bundle organization in vascular smooth muscle cells with impaired actin polymerization, revealing destabilizing effects on bundle connectivity.

A time-delayed mechanochemical feedback model reconciles stable maintenance and dynamic remodeling of cell-matrix adhesions

The paper develops a time-delayed mechanochemical model to explain how stable adhesion maintenance and dynamic remodeling of cell-matrix adhesions can arise from feedback mechanisms.

A closed-loop mathematical structure of mechanics-turnover coupling for mechanical adaptation in living systems

The paper identifies the minimal mathematical structure of mechanics-turnover coupling that enables mechanical homeostasis and derives an analytical expression for adaptation timescale.

AI-assisted imaging screening reveals mechano-molecular tissue organizers and network of signaling hubs.

The paper uses AI-assisted imaging and gene silencing to identify key proteins regulating epithelial tissue mechanics and their roles in cancer.

SERPINE1-AP2A1 interplay links substrate stiffness to fibroblast senescence

This study shows that substrate stiffness influences fibroblast senescence through the SERPINE1-AP2A1 interaction, affecting cytoskeletal remodeling and senescence-associated secretory phenotype factors.

Mechanical contributions of the Myp2 tail revealed by coiled-coil force sensors

This study measures forces on Myp2 in fission yeast using force sensors, showing the C-terminal tail significantly contributes to force transmission during cytokinesis.

Energetically constrained turnover drives the emergence of aging

This study shows that aging emerges from unavoidable damage and energetically constrained turnover, demonstrating that these factors can generate aging-like decline in biological systems.

Impacts of Structural Properties of Myosin II Filaments on Force Generation

This study uses an agent-based model to show how structural properties of myosin II filaments affect force generation in actomyosin structures.

Dissecting Molecular Origins of the Mechano-Adaptive Behaviors of Actomyosin Bundles

This study investigates how actomyosin bundles adapt to mechanical stress through experiments and simulations, revealing rate-dependent behaviors and key factors influencing their response.

Emergence of Pareto distributions in intracellular protein activity through interaction-driven modulation

This study explains how power-law distributions of protein activity emerge from interaction-driven feedback mechanisms without intrinsic heterogeneity.

Mapping molecular diffusion across the whole cell with spatial statistics-based FRAP

This paper introduces Pro-FRAP, a method that enhances FRAP analysis to map whole-cell molecular diffusion with improved spatial coverage and statistical reliability.

Decoupling diffusion, turnover, and advection in long-term FRAP

This paper develops a framework to analyze long-term FRAP data by incorporating diffusion, turnover, and advection, revealing how advection can drive fluorescence recovery independently of diffusion and reaction kinetics.

Knowledge "installed" diffusion model predicts the geometry of actin cytoskeleton from cell morphology

The paper introduces a diffusion model that predicts stress fiber distribution from cell morphology, achieving 79.3% overlap with experimental data and revealing geometric relationships.