Takumi Saito

This study shows that substrate stiffness influences fibroblast senescence through the SERPINE1-AP2A1 interaction, affecting cytoskeletal remodeling and senescence-associated secretory phenotype factors.

This study measures forces on Myp2 in fission yeast using force sensors, showing the C-terminal tail significantly contributes to force transmission during cytokinesis.

This study uses coiled-coil force sensors to measure force transmission along the formin Cdc12 in fission yeast, revealing distinct mechanisms upstream and downstream of the FH2 domain.

This paper introduces Pro-FRAP, a method that enhances FRAP analysis to map whole-cell molecular diffusion with improved spatial coverage and statistical reliability.

This paper develops a framework to analyze long-term FRAP data by incorporating diffusion, turnover, and advection, revealing how advection can drive fluorescence recovery independently of diffusion and reaction kinetics.

This paper introduces genetically encoded mechano-sensors using coiled coils to measure mechanical forces in vivo with diverse readouts and compact design.