Cholesterol sensing by CD81 is important for hepatitis C virus entry
Machaela Palor, Lenka Stejskal, Piya Mandal, Annasara Lenman, María Pía Alberione, Jared Kirui, Rebecca A. Moeller, Stefan Ebner, Felix Meissner, Gisa Gerold, Adrian J. Shepherd, Joe Grove
This study investigates how CD81 senses cholesterol and how this affects its function as a hepatitis C virus receptor, finding that cholesterol binding regulates CD81's conformation and receptor activity.
Journal of Biological Chemistry · Sep 8, 2020Peer-reviewedMolecular Biology