Encephalitic alphavirus infection reduces neurite outgrowth and downregulates Rho GTPase pathways in human iPSC-derived neurospheres
Karsten Cirksena, Lisa Maria Haiber, Britta Anna Kühne…·Gisa Gerold
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Innsbruck Medical UniversityORCID 0000-0002-1326-5038Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
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Karsten Cirksena, Lisa Maria Haiber, Britta Anna Kühne…·Gisa Gerold
Anja C. M. de Bruin, Enzo Mameli, Lathika Valliyott…·Gisa Gerold
The paper uses a pro-apoptotic CRISPR screening strategy in mosquito cells to identify Lachesin as a critical CHIKV entry factor.
Jesse S. Plung, Enzo Mameli, Wanyu Li…·Jonathan Abraham
This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.
Francesco Costacurta, Andrea Dodaro, Albert Falch…·Emmanuel Heilmann
This study develops a dual-chimeric virus to safely study antiviral resistance and cross-resistance using spike and protease inhibitors.
Nele Villabruna, Myra D.T. Hosmillo, Ian Goodfellow…·Gisa Gerold
This study develops an ex vivo model to investigate zoonotic transmission of noroviruses, showing human norovirus can bind and replicate in pig tissue but not chicken tissue.
Fakhar H. Waqas, Francisco José Zapatero Belinchón, Madalina Elena Carter-Timofte…·Frank Peßler
This paper shows NRF2 activators inhibit coronaviruses by downregulating ACE2, TMPRSS2, and XPO1, independent of NRF2 signaling.
Thi Ngan Dong, Graham Brogden, Gisa Gerold, Megha Khosla
The paper develops a multitask transfer learning framework to predict virus-human protein interactions using statistical protein representations from a large sequence corpus, showing improved performance on benchmark datasets.
Machaela Palor, Lenka Stejskal, Piya Mandal…·Joe Grove
This study investigates how CD81 senses cholesterol and how this affects its function as a hepatitis C virus receptor, finding that cholesterol binding regulates CD81's conformation and receptor activity.