Sequential adaptor function of Treacle and MDC1 couples nucleolar reorganization to RNF8-dependent recruitment of HDR factors
Andrea Haenel, Johannes Leyrer, Polyxenia Stutz, Manuel Stucki
The paper shows that Treacle and MDC1 sequentially coordinate nucleolar reorganization and HDR factor recruitment to restrict DNA repair to the nucleolar periphery.
bioRxiv · Apr 21, 2025 · PreprintCell Biology