Author

Johannes Leyrer

University Hospital ZurichORCID 0009-0007-7282-4278Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Manuel StuckiiD· 2 shared Alain Jeanrenaud· 1 shared Andrea Haenel· 1 shared Andrea HäneliD· 1 shared Angelos ConstantinouiD· 1 shared Clémence MooseriD· 1 shared Jihane BasbousiD· 1 shared Mònica Torres Esteban· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Manuel StuckiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 21, 2026

Chromatin adaptors and TOPBP1 condensates cooperate to organize ATM signaling

Clémence Mooser, Jihane Basbous, Nathalie Varisco…·Manuel Stucki

This study identifies Treacle and NBS1 as components of TOPBP1 condensates that activate ATM signaling and show their cooperative role in organizing DNA damage responses.

DOI 10.64898/2026.08.21.746129

experimental assaychromatin & epigenetic regulation

𝕏 PostBluesky

Cell BiologybioRxivPreprintApr 21, 2025

Sequential adaptor function of Treacle and MDC1 couples nucleolar reorganization to RNF8-dependent recruitment of HDR factors

Andrea Haenel, Johannes Leyrer, Polyxenia Stutz, Manuel Stucki

The paper shows that Treacle and MDC1 sequentially coordinate nucleolar reorganization and HDR factor recruitment to restrict DNA repair to the nucleolar periphery.

1 citation

DNA methylationChIP-seq

𝕏 PostBluesky