Manuel Stucki

Chromatin adaptors and TOPBP1 condensates cooperate to organize ATM signaling

This study identifies Treacle and NBS1 as components of TOPBP1 condensates that activate ATM signaling and show their cooperative role in organizing DNA damage responses.

CIP2A Mediates the Recruitment of the SLX4-MUS81-XPF Tri-Nuclease Complex in Mitosis and Protects Against Replication Stress

This paper shows CIP2A recruits the SMX tri-nuclease complex to manage under-replicated DNA during mitosis, preventing chromosome segregation errors in HRD cancers.

ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

This study shows ARID1A deficiency increases sensitivity to the G4 ligand pyridostatin due to impaired DNA repair, highlighting a role for ARID1A in G4 ligand-induced DNA damage responses.

Sequential adaptor function of Treacle and MDC1 couples nucleolar reorganization to RNF8-dependent recruitment of HDR factors

The paper shows that Treacle and MDC1 sequentially coordinate nucleolar reorganization and HDR factor recruitment to restrict DNA repair to the nucleolar periphery.

MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks

This study identifies MDC1 as a mediator of Pellino1 and Pellino2 recruitment to DNA double-strand breaks through phosphorylation-dependent interactions.