Diabetic liver-enriched secretory dipeptidyl peptidase 4 (DPP4) fuels gut inflammation via attenuation of autophagy
Mohammad Athar, Ratulananda Bhadury, Chayanika Gogoi, Pooja Mishra, Prity Kumari, Manisha Yadav, Jaswinder Singh Maras, Devram Sampat Ghorpade
This study identifies liver-enriched DPP4 as a driver of gut inflammation in diabetes by inhibiting autophagy, leading to increased immune cell infiltration and colitis.
bioRxiv · Aug 6, 2024 · PreprintPhysiology