Angiotensin II Type 1 Receptor Blockade Inhibits Gastric Cancer Metastasis Through Tight Junction Restoration
Sooraj Kakkat, Prabhat Suman, Sandeep Goswami, Brusi Kola, Kira Bruno, Wendy L. Frankel, Sujit Basu, Elba A. Turbat‐Herrera, Verónica Ramírez‐Alcántara, Martin J. Heslin, Joel Andrews, Paramahansa Pramanik, Chandrani Sarkar, Debanjan Chakroborty
This study shows that blocking the angiotensin II type 1 receptor reduces gastric cancer metastasis by restoring tight junctions through mechanisms involving KLF4 and TJ protein expression.
Cancer Letters · May 2, 2026Peer-reviewedCancer Biology