Author

Joel Andrews

USA Mitchell Cancer InstituteORCID 0000-0001-9596-6497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Aishwarya PrakashiD· 2 shared A. DeweeveriD· 1 shared Andrzej Wierzbicki· 1 shared Brusi Kola· 1 shared Camryn Hall· 1 shared Chandrani SarkariD· 1 shared Christopher A. KoczoriD· 1 shared Debanjan ChakrobortyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Aishwarya PrakashORCID

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3 papers

Recent·Most cited

Angiotensin II Type 1 Receptor Blockade Inhibits Gastric Cancer Metastasis Through Tight Junction Restoration

Sooraj Kakkat, Prabhat Suman, Sandeep Goswami, Brusi Kola, Kira Bruno, Wendy L. Frankel, Sujit Basu, Elba A. Turbat‐Herrera, Verónica Ramírez‐Alcántara, Martin J. Heslin, Joel Andrews, Paramahansa Pramanik, Chandrani Sarkar, Debanjan Chakroborty

This study shows that blocking the angiotensin II type 1 receptor reduces gastric cancer metastasis by restoring tight junctions through mechanisms involving KLF4 and TJ protein expression.

Cancer Letters · May 2, 2026Peer-reviewedCancer Biology

PPM1B utilizes a trinuclear metal architecture for phosphatase activity

Reece P. Stevens, Viktoriya Solodushko, Andrzej Wierzbicki, Thomas C. Rich, Mikael F Alexeyev, Marlo K. Thompson, Madeline Stone, Camryn Hall, A. Deweever, Sarah Sayner, Troy Stevens, Joel Andrews, Aishwarya Prakash, Richard E. Honkanen, Ji Young Lee, , Mark R. Swingle

This study identifies a trinuclear metal center in PPM1B that facilitates phosphate hydrolysis through direct substrate coordination and water protonation, revealing a novel catalytic mechanism.

bioRxiv · Apr 27, 2026 · PreprintBiochemistry

Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage

Rasha Q. Al‐Rahahleh, Wynand Paul Roos, Kate M. Saville, Joel Andrews, Zhijin J. Wu, Christopher A. Koczor, Aishwarya Prakash, Robert William Sobol

The paper evaluates WWE and macrodomain proteins as PAR probes in live cells and shows unique PAR dynamics that can modulate the DNA damage response.

DNA repair · May 21, 2025Peer-reviewedMolecular Biology