Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy
Min‐Hsuan Lin, Pramila Maniam, Dongsheng Li, Bing Tang, Cameron Bishop, Andreas Suhrbier, Lucy Wales-Earl, Yaman Tayyar, Nigel A.J. McMillan, Li Li, David Harrich
This paper demonstrates that DI290-loaded lipid nanoparticles (LNP-290) effectively suppress DENV infection in cell cultures and mice, inducing IFN responses and preventing clinical signs.
Molecular Therapy — Nucleic Acids · Dec 12, 2024Peer-reviewedMicrobiology