MicrobiologyMolecular Therapy — Nucleic AcidsPeer-reviewed
Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy
Min‐Hsuan Lin, Pramila Maniam, Dongsheng Li…·David Harrich
This paper demonstrates that DI290-loaded lipid nanoparticles (LNP-290) effectively suppress DENV infection in cell cultures and mice, inducing IFN responses and preventing clinical signs.