Author

Nigel A.J. McMillan

Griffith UniversityORCID 0000-0002-9471-1406Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Yaman TayyariD· 2 shared Adi IdrisiD· 1 shared Alicia M. DavisiD· 1 shared Andreas SuhrbieriD· 1 shared Ariel Andrew· 1 shared Aroon SupramaniamiD· 1 shared Bing TangiD· 1 shared Brian G. GabrielliiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersMicrobiology

Yaman TayyarORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.

Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina A. Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew V. Jones, Yaowu He, John David Hooper, Nigel A.J. McMillan, Jelena Urosevic, Jamal Carlos Saeh, , Brian G. Gabrielli

This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.

Cell Death and Disease · Jan 8, 2025Peer-reviewedCell Biology

Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy

Min‐Hsuan Lin, Pramila Maniam, Dongsheng Li, Bing Tang, Cameron Bishop, Andreas Suhrbier, Lucy Wales-Earl, Yaman Tayyar, Nigel A.J. McMillan, Li Li, David Harrich

This paper demonstrates that DI290-loaded lipid nanoparticles (LNP-290) effectively suppress DENV infection in cell cultures and mice, inducing IFN responses and preventing clinical signs.

Molecular Therapy — Nucleic Acids · Dec 12, 2024Peer-reviewedMicrobiology

A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

Adi Idris, Alicia M. Davis, Aroon Supramaniam, Dhruba Acharya, Gabrielle Kelly, Yaman Tayyar, Nicholas P. West, Ping Zhang, Christopher L. D. McMillan, Citradewi Soemardy, Roslyn Michelle Ray, Denis O’Meally, Tristan A. Scott, Nigel A.J. McMillan, Kevin V. Morris

This paper develops an siRNA-nanoparticle therapy targeting SARS-CoV-2 that reduces viral load and improves survival in mice.

Molecular Therapy · May 13, 2021Peer-reviewedSynthetic Biology