Systematic Engineering of Intra-Articular Drug Release Profiles Reveals a Key Determinant of Disease-Modifying Efficacy in Post-Traumatic Osteoarthritis
Jingjing Gao, Nutan Bhingaradiya, Ziting Judy Xia, Ryan Yip, Eli Weldon, Chilan Bou Chosson Leite, Nishkal Dhiraj Pisal, Swetharajan Gunasekar, Pranav Chandrasekar, Paula Oliva Ribas, Mahima Dewani, Christopher Jiang, Gopinathan Janarthanan, Alexandra Dolliver, Chu Wai Chun Rachel, , Nitin Joshi
This study shows that slower, sustained drug release from hydrogels improves therapeutic outcomes in post-traumatic osteoarthritis compared to faster release.
bioRxiv · Jun 3, 2026 · PreprintBioengineering