Jeffrey M. Karp

Systematic Engineering of Intra-Articular Drug Release Profiles Reveals a Key Determinant of Disease-Modifying Efficacy in Post-Traumatic Osteoarthritis

This study shows that slower, sustained drug release from hydrogels improves therapeutic outcomes in post-traumatic osteoarthritis compared to faster release.

A Precisely Controlled Long-Acting Immunosuppression Platform Enables Prolonged Survival of Vascularized Composite Allografts

PRECISE, a long-acting immunosuppression platform, maintains therapeutic drug levels and prolongs graft survival in VCA models through precise control of tacrolimus and rapamycin release.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

Robust differentiation of human enteroendocrine cells from intestinal stem cells

This study develops a method to differentiate human intestinal stem cells into functional enteroendocrine cells using small molecule targeting of specific signaling pathways.

A conjugation platform for CRISPR-Cas9 allows efficient β-cell engineering

This paper introduces a CRISPR-Cas9 conjugation platform for multivalent display of molecules, enhancing genome editing precision and enabling β-cell engineering to secrete interleukin-10.