Establishment of a Reverse Genetics System for the Study of Human Immune Functions in Mice
Priya Pal, Shuai Gao, Hongbo Gao, Marina Cella, Qiankun Wang, Liang Shan
This paper establishes a method to generate humanized mice with targeted gene knockouts in the human immune system using Cas9-edited CD34+ cells.
bioRxiv · Mar 26, 2025 · PreprintImmunology