Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks
Andrew J. Fritz, Haley W. Greenyer, Louis Dillac, Priyanka Chavarkar, Rahim Ullah, Miles Malik, Deli Hong, Rabail Hassan Toor, Emory Pacht, Abigail G. Person, Georgiy Zotkin, Sadie J Korzec, Cong Gao, Alquassem Abuorquob, Janine S. A. Warren, , Gary S. Stein
This study shows that acute RUNX1 loss reprograms enhancer activity, leading to epithelial destabilization and cancer hallmark activation in human mammary epithelial cells.
bioRxiv · Mar 28, 2026 · PreprintCancer Biology