Author

Andrew J. Fritz

University of VermontORCID 0000-0002-2220-9943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gary S. SteiniD· 4 shared Haley W. GreenyeriD· 3 shared Jane B. LianiD· 3 shared Janet Lee SteiniD· 3 shared Seth E. FrietzeiD· 3 shared Deli HongiD· 2 shared Emory Pacht· 2 shared Janine S. A. WarreniD· 2 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Gary S. SteinORCID

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4 papers

Recent·Most cited

Genome reorganization and its functional impact during breast cancer progression

Kathleen S Metz Reed, Andrew J. Fritz, Haley W. Greenyer, Kerstin Heselmeyer‐Haddad, Seth E. Frietze, Janet Lee Stein, Gary S. Stein, Tom Misteli

The paper profiles genome organization changes during breast cancer progression using Micro-C mapping and links these changes to gene expression and enhancer activity.

eLife · Jun 16, 2026Peer-reviewedGenomics

lncRNA MANCR isoforms selectively mediate multiple levels of epigenomic and P53-responsive transcriptional control in triple negative breast cancer

Emory Pacht, Janine S. A. Warren, Rabail Hassan Toor, Karen C. Glass, Haley W. Greenyer, Andrew J. Fritz, Bodhisattwa Banerjee, Seth E. Frietze, Jane B. Lian, Jonathan Gordon, Gary S. Stein, Janet Lee Stein

The paper identifies MANCR isoforms' roles in epigenomic and P53-responsive transcriptional control in TNBC through computational and experimental methods.

bioRxiv · Apr 8, 2026 · PreprintCancer Biology

Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks

Andrew J. Fritz, Haley W. Greenyer, Louis Dillac, Priyanka Chavarkar, Rahim Ullah, Miles Malik, Deli Hong, Rabail Hassan Toor, Emory Pacht, Abigail G. Person, Georgiy Zotkin, Sadie J Korzec, Cong Gao, Alquassem Abuorquob, Janine S. A. Warren, , Gary S. Stein

This study shows that acute RUNX1 loss reprograms enhancer activity, leading to epithelial destabilization and cancer hallmark activation in human mammary epithelial cells.

bioRxiv · Mar 28, 2026 · PreprintCancer Biology

RUNX1 suppresses breast cancer stemness and tumor growth

Deli Hong, Andrew J. Fritz, Kristiaan H. Finstad, Mark P. Fitzgerald, Adam L. Viens, Jon Ramsey, Janet L. Stein, Jane B. Lian, Gary S. Stein

This study shows that Runx1 suppresses breast cancer stemness and tumor growth by inhibiting Zeb1 and epithelial-mesenchymal transition.

bioRxiv · May 4, 2018 · PreprintCancer Biology