Cancer BiologybioRxivPreprint
Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks
Andrew J. Fritz, Haley W. Greenyer, Louis Dillac…·Gary S. Stein
This study shows that acute RUNX1 loss reprograms enhancer activity, leading to epithelial destabilization and cancer hallmark activation in human mammary epithelial cells.
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